Bioactivation of the human carcinogen aristolochic acid
نویسندگان
چکیده
منابع مشابه
The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.
UNLABELLED Aristolochic acid I (AAI) is the major toxic component of the plant extract AA, which leads to the development of nephropathy and urothelial cancer in human. Individual susceptibility to AAI-induced disease might reflect variability in enzymes that metabolise AAI. In vitro NAD(P)H quinone oxidoreductase (NQO1) is the most potent enzyme that activates AAI by catalyzing formation of ...
متن کاملBioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. Individual susceptibility to AA-induced disease likely reflects individual differences in enzymes that metabolize AA. Herein, we evaluated AAI metabolism by human cytochrome P450 (CYP) 1A1 and 1A2 in two CYP1A-humanized mouse lines that carry functional human CYP1A1 and CYP1A2 genes in the absence of ...
متن کاملNAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Aristolochic acid causes a specific nephropathy (AAN), Balkan endemic nephropathy, and urothelial malignancies. Using Western blotting suitable to determine protein expression, we investigated in several transgenic mouse lines expression of NAD(P)H:quinone oxidoreductase (NQO1)-the most efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI). The mouse tissues used were ...
متن کاملAristolochic acid, an herbal carcinogen, sold on the Web after FDA alert.
to the editor: In 2001, the Food and Drug Administration (FDA) issued warnings and an import alert that herbal products are unsafe if they contain or are suspected to contain aristolochic acid.1 A report in the Journal in 2000 described a cohort of 105 patients in whom rapidly progressive nephropathy developed after they had been given an herbal weight-loss product containing aristolochic acid ...
متن کاملPlants Containing Aristolochic Acid
For the purpose of this Monograph, unless otherwise specified, the term ‘aristolochic acids’ refers to an extract of Aristolochia species comprising a mixture of aristolochic acid I and its demethoxylated derivative, aristolochic acid II. Aristolochia species also contain the related aristolactams, which are phenanthrene cyclic amides (EMEA, 2000). In some of the older literature, it is unclear...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2014
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgu095